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Dr. William Kaufman,
B-3 and Arthritis |
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Arthritis Notes |
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Reprinted with permission
from Saul AW. William Kaufman, B-3, and arthritis. J Orthomolecular Med,
2001. Vol. 16, No. 3, Third Quarter, 2001, p 189. The world was still deep
in the Great Depression
when William Kaufman, MD, PhD, had already begun treating osteoarthritis with
two to four grams of niacinamide daily. Now, over 60 years later, his
pioneering work in orthomolecular medicine is receiving the recognition it so
well deserves. In a 1978 radio interview
with Carlton Fredericks, Dr Kaufman told of how "I had one patient who
was so severely arthritic that I could not bend his elbows enough to measure
his blood pressure. He was one of my first patients. I gave him niacinamide
for a week in divided doses, and then he could bend his arm. I took him
off it and gave him a look-alike medicine (placebo). In a week he was back
where he was before: his joints were stiff again. "I arrived at my
(megavitamin B-3 dosage) schedule by actually seeing the response of patients
with varying degrees of arthritis. One cannot give a single large dose and
get any really favorable results in arthritis... It is necessary to divide
the doses so that the blood levels of niacinamide would be fairly uniform
throughout the waking day." Kaufman's findings were
both plain and elegant. The greater the stiffness, the more frequent the
doses. Severely crippled arthritic patients needed up to a total of 4,000
mg/day. Divided into 10 doses per day, in one to three months, patients
could now get out of their chair, or bed. "If continued, they
would be able comb their hair and be able to walk upstairs, so they would no
longer be prisoners of the house. By the end of about three years treatment,
they would be fully ambulatory, and this was even in the older age
groups." (To order a mint-condition, hardcover copy of the very
rare, original 1949 edition of Dr Kaufman’s book, The Common Form of Joint Dysfunction (194 pages plus references),
please click here.) (If you would like to own a mint-condition, hardcover copy
of the extremely rare, original 1943 Yale University Press edition of The Common Form of Niacin Amide Deficiency Disease: Aniacinamidosis, please click here.) Niacinamide therapy for
joint mobility. Niacinamide, a most neglected
vitamin. 1978 Tom Spies Memorial Lecture. J. Int. Acad. of Preventive Med.
8:5-25,1983 Niacinamide improves
mobility in degenerative joint disease. Abstract published in Program of
the American Association for the Advancement of Science for its meeting
in Dr. Kaufman's complete
bibliography is posted at
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