||Dangers of Caffeine, with References|
|Caffeine Induced Anaphylaxis,
A Progressive Toxic Dementia
Copyright 2002 Ruth Whalen, MLT, ASCP. Reprinted with permission of the author.
Cerebral allergy is an allergy to a substance,
which targets vulnerable brain tissue and alters brain function. Masked
cerebral allergy can cause symptoms of mental illness (Walker, 1996; Rippere,
1984; Sheinken et al., 1979). Symptoms range from minimal reactions to
severe psychotic states, which may include irrational behavior, disruptions
in attention, lack of focus and comprehension, mood changes, lack of organizational
skills, abrupt shifting of activities, delusions, hallucinations, and paranoia
(Sheinken et al., 1979; McManamy et al., 1936).
Caffeine anaphylaxis interferes with the ability to focus. Sitting still becomes a project. Raising the catecholamine level, caffeine produces additional dopamine, which increases locomotive movement. Agitation is associated with excess dopamine (Carter, 1998).
Caffeine causes faster speech and mobility in children (Nehlig et al., 1992). With 80% of the world’s population consuming caffeine, most persons have remained stimulated since childhood. Stimulated adults can’t detect caffeine-induced changes in themselves or in children. Misjudging a child’s natural state, adults assume children should speak and act at the same rate as stimulated adults. People forget that we are born relaxed. Acceleration of speech and action indicates mania (Victor et al., 2001; Restak, 1984), associated with bipolar affective disorder. Manic symptoms affect children. Psychiatrically hospitalized manic children display symptoms of ADD (Carlson et al., 1998).
Complaints of lack of focus, failing memory, and other mental abnormalities, signify hypomania, a lesser degree of mania (Victor, 2001), which accompanies the first stage of ongoing-caffeine-induced-anaphylaxis-induced fight or flight dementia. Unable to correlate the patient’s complaints with a textbook disorder, physicians assume ADD.
According to the American Psychiatric Association, which classifies caffeine as a substance, substance intoxication can present with disturbance in thinking, judgment, perception, attention, motor activity, and social functioning (1994). Caffeine toxicity can induce restlessness, agitation, irritability, confusion, and delerium (Steinman, 2001; Fisher Scientific, 1997; Turkington, 1994; Shen et al., 1979). In addition, anaphylaxis can induce delerium (Kaplan, 2000).
Unlike Stephen Cherniske, aware of instinct warning him that caffeine was affecting his behavior (Cherniske, 1998), a child does not know. A youngster can’t feel the mild stimulant rush because the underdeveloped body has developed a tolerance. Similarly, a toxic adult loses natural insight and can’t recognize caffeine induced intellect and personality changes (Shen, 1979; McManamy, 1936; Crothers, 1902).
During partial withdrawal, the body metabolizes some caffeine, saturating cells. Clarity struggles to return. Symptoms of partial withdrawal can overlap traits of poisoning (Strain et al., 1997) and can mimic depression (Hirsch, 1984). As the noradrenaline level diminishes, symptoms of depression set in (Restak, 1994, Ackerman, 1992). Caffeine induced withdrawal depression can manifest as hyperactivity, lethargy, irritability, confusion, and lack of focus. The glucose level, which rises along with adrenaline (Davidson et al., 1969) and remains elevated during the body’s struggle to maintain homeostasis, drops. A decrease in glucose encourages lack of motivation, which may also mimic depression.
As Allbutt and Dixon stressed, in 1909, regarding caffeine, another “dose of the poison” provides minor relief, but continues to jeopardize organs (1909). A return to caffeine intake increases noradrenaline, heightening the fight or flight response. In turn, adrenaline, dopamine, and glucose increase, thus lifting depression. With continued substance exposure, toxins accumulate (Van Winkle, 2000).
Caffeine allergy is a deceptive allergy. Ongoing caffeine anaphylaxis reduces allergic inflammation and maintains organ stimulation. Endogenous glucocorticoids (including cortisol) inhibit inflammation (Claman, 1983). Theophylline is the principle therapy for asthma. All forms of theophylline maintain open bronchial passages, allowing for easier breathing. During ongoing caffeine anaphylaxis, airways remain open.
Adrenaline, the drug of choice for anaphylaxis, is always present in a caffeine consumer. By suppressing phosphodiesterase release, caffeine (Davidson, 1969) increases cyclic AMP. Excess amounts of cyclic AMP inhibit histamine production (Dykewicz, 2001; Ernst et al., 1999). Phosphodiesterase inhibitors inhibit histamine release (Raderer et al., 1995).
Cyclic AMP is increased in patients diagnosed as schizophrenic and many individuals diagnosed with affective disorders (Nishino et al., 1993; Erban et al., 1980; Biederman et al., 1977). Histamine is reduced in persons diagnosed with schizophrenia, a late stage of ongoing caffeine anaphylaxis.
Although the histamine level is low in schizophrenics (Malek-Ahmadi et al., 1976; Hoffer et al., 1967), schizophrenic patients exhibit a marked tolerance to histamine (Lea, 1955). This suggests, in the case of caffeine anaphylaxis, that during the onset stage of schizophrenia, when anaphylaxis induced hyperactivity, or anaphylaxis induced panic symptoms were mistaken as ADD, anxiety, or panic, (before continued cerebral poisoning), histamine was increased but the allergy went undetected.
Symptoms of allergic anxiety (Bonner, 2000; Kaplan, 2000; Walsh, 2000) may be mistaken as anxiety neurosis, considered an onset symptom of schizophrenia. When a young person experiencing a first anxiety episode arrives in an emergency room, doctors suspect a developing schizophrenia (Victor, 2001).
Attention and memory deficits accompany schizophrenia (Zuffante et al., 2001; Goldberg et al., 1993). Researchers theorize that prior to the onset of schizophrenia changes in a person’s cognition may be subtle (Goldberg, 1993).
Chlorpromazine (Thorazine) and other phenothiazine drugs exhibit an anti-histamine effect (Sifton, 1994; Malek-Ahmadi, 1976), similar to diphenhydramine (Benadryl). A person allergic to caffeine, taking a phenothiazine medication, will experience relief of the physical manifestations of ongoing caffeine anaphylaxis. In addition, phenothiazine medications reduce allergic induced abnormal psychological symptoms, including a reduction in paranoia, hallucinations, and delusions, and generate a return of partial insight, focus, and comprehension.
Ongoing caffeine allergy induces a progressive toxic dementia (McManamy, 1936). In a caffeine allergic person, each caffeine or theophylline dose increases toxin accumulation. A buildup of caffeine, which may exceed tolerance level, saturates the ability of metabolism (Carrillo et al., 2000; Nehlig, 1999); rate of drug accumulation exceeds rate of elimination. Introducing a stimulant into a caffeine allergic individual’s system will further poison the frontal cortex and hypothalamus and continue to mask allergic symptoms of caffeine anaphylaxis. Continued stimulant use increases toxic psychosis, which results in decreased affect and deterioration of mental abilities.
Ackerman. Sandra. Discovering The Brain. Washington: National Academy Press, 1992.
Allbutt, Clifford T. A System of Medicine. VII. Part I. London: MacMillan, 1909.
Allen, Thomas E., Park, Lee Crandall, Lieberman,
Mayer C. and William Wimmer.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders Fourth Edition. Washington: APA, 1994.
Biederman, J., Rimon, R., Ebstein, R., Belmaker, H., Davidson, J.T. Cyclic AMP in the CSF of patients with schizophrenia. Br J Psychiatry, 130 (1977): 64-67.
Bonner, James R. “Drug Allergy” in Cecil Textbook of Medicine. Goldman, Lee and Claude J. Bennett, eds. Philadelphia: W.B. Saunders, 2000.
Braun, Stephen. Buzz: The Science and Lore of Alcohol and Caffeine. New York: Penguin, 1997.
Carlson, G.A., Kelly, K.L. Manic symptoms in psychiatrically hospitalized children---what do they mean? J Affect Disord, 51(1998): 123-135.
Carrillo, J.A., Benitz, J. Clinically significant pharmokinetic interactions between Dietary caffeine and medications. Clin Pharmacokinet, 39 (2000): 127-153.
Carter, Rita. Mapping the Mind. Berkeley, CA.: University of California Press, 1998.
Cherniske, Stephen. Caffeine Blues: Wake Up to the Hidden Dangers of America's #1 Drug. New York: Warner, 1998.
Claman, H.N. Glucocorticosteroids I: anti-inflammatory mechanisms. Hosp Pract, 18 (1983): 123-126.
Crothers, T.D. Morphinism and Narcomanias from other Drugs. Philadelphia: W. B. Saunders & Co., 1902.
Davidson, John and John Bernard Henry. Todd-Sanford Clinical Diagnosis by Laboratory Methods. Philadelphia: W. B. Saunders, 1969.
Dykewicz, M.S. Anaphylaxis and inflammation. Clin Allergy Immunol, 16 (2001): 401-409.
Eliot, Lise. What’s Going on in There? : How the Brain and Mind Develop in the First Five Years of Life. New York: Bantam, 1999.
Erban, L., Prokes, J., Richtrova, E. Plasma level of cyclic AMP and mental diseases. Act Nerv Super, 22 (1980): 269-273.
Ernst, M.E., Graber, M.A. Methylxanthine use in anaphylaxis: what does the evidence tell us? Ann Pharmacother, 33(1999): 1001-1004.
Fisher Scientific Corporation. Material Safety Data Sheet: Caffeine. New Jersey: MDL Information Systems, 1997.
Goldberg, T.E., Hyde, T.M., Kleinman, J.E, Weinberger, D.R. Course of schizophrenia: neuropsychological evidence for a static encephalopathy. Schizophr Bull, 19 (1993): 797-804.
Headlee, Raymond. Psychiatry in Nursing. New York: Rhinehart & Company, 1948.
Hirsch, Kenneth. “Central Nervous System Pharmacology of the Dietary Methylxanthines” in The Methylxanthines Beverages and Foods: Chemistry, Consumption, and Health Effects. Spiller, Gene A., ed. New York: Alan R. Liss Inc., 1984.
Hoffer, A. and Osmond, H. The Hallucinogens. New York: Academic Press, 1967.
Jacques, Alan. Understanding Dementia. London: Churchill Livingston, 1992.
Kaplan, Allen, P. “Anaphylaxis” in Cecil Textbook of Medicine. Goldman, Lee and Claude J. Bennett, eds. Philadelphia: W.B. Saunders, 2000.
Lea, A.J. Adrenochrome as the cause of schizophrenia: investigation of some deductions from this hypothesis. J Mental Sci, 101 (1955): 538-547.
Malek-Ahmadi, P., and Fried, F.E. Biochemical correlates of schizophrenia. Compr Psychiatry, 17 (1976): 499-509.
McManamy, M.C., Schube, P.G. Caffeine intoxication: report of a case the symptoms of which amounted to a psychosis. N Engl J Med, 215 (1936): 616-620.
Miller, C. S. Toxicant-induced loss of tolerance—an emerging theory or disease? Environ Health Perspect, 105 (1997): 445-453.
Nehlig, A., Daval, J., Debry, G. Caffeine and the central nervous system: Mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Rev, 17 (1992): 139-170.
Nehlig, A. Does caffeine lead to psychological dependence? Chemtech, 29 (1999): 30-35.
Nishino, N., Kitamura, N., Hashimoto, T., Kajimoto, Y., Shirai, Y., Murakami, N., Nakai, T., Komure, O., Shirakawa, O., Mita, T., et al. Increase in [3H] cAMP binding sites and decrease in Gi alpha and Go alpha immunoreactivities in left temporal cortices from patients with schizophrenia. Brain Res, 615 (1993): 41-49.
NTP Chemical Repository. Material Safety Data Sheet: Caffeine. Radian Corporation, 1991. http://126.96.36.199/NTP_Reports/NTP_Chem_H&S/NTP_Chem5/Radian58-08-2.txt. Oct. 2001.
Przybilla, B., Ring, J., Burg, G. [Anaphylaxis following ingestion of coffee, chronic urticaria and analgesics idiosyncrasy.] Hautarzt, 34 (1983): 73-76. National Institutes of Health: Med-Line.
Raderer, I., Haen, E., Schudt, C., Przybilla, B. [Inhibition of histamine liberation in allergic rhinoconjunctivitis in relation to the season.] Wien Med Wochenschr, 145 (1995): 456-8. National Institutes of Health: Med-Line.
Restak, Richard M. Receptors. New York: Bantam Books, 1994.
Rippere, V. Some varieties of food intolerance in psychiatric patients: an overview. Nutr Health, 3(1984): 125-136.
Serafin, William. “Drugs Used in the Treatment of Asthma,” in Goodman and Gilman’s The Pharmacological Basis of Therapeutics. Ninth Edition. Hardman, Joel G., Limbird, Lee E., and Perry B. Molinoff Perry B, eds. New York: Mc-Graw Hill, Health Professions Division, 1996.
Sheinken, David, Michael Schachter and Richard Hutton. The Food Connection: How the Things You Eat Affect the Way You Feel-And What You Can Do About It. New York: Bobbs-Merrill Co., 1979.
Shen, W.W., D'Souza, T.C. Cola-induced psychotic organic brain syndrome: A case report. Rocky Mount Med Journ, 76 (1979): 312-313.
Sifton, David. W, ed. Physicians’ Desk Reference.48th ED. Montvale, New Jersey: Medical Economics Data Production Co., 1994.
Steinman, H. Food Intolerance-Selected Topics 2. Allergy Society of South Africa. <Http://www.allergysa.org/html/caffeine.html>. Oct. 2001.
Strain, E.C., Griffiths, R.R. “Caffeine use disorders” in Psychiatry. V. I. A. Tasman, J. Kay, J.A. Lieberman, eds. Philadelphia: W.B. Saunders Co., 1997. (Courtesy of Griffiths, R.R.)
Turkington, Carol. Foreword by Osterhout, Shirley. “Caffeine” in Poisons and Antidotes, 2nd ED. New York: Facts on File, 1994.
Van Winkle, E. The toxic mind: the biology of mental illness and violence. Medical Hypothesis, 55 (2000): 356-368.
Victor, Maurice and Allan Ropper. Adam’s and Victor’s Principles of Neurology. New York: McGraw-Hill, 2001.
Walker, Sydney III. A Dose of Sanity: Mind, Medicine, and Misdiagnosis. New York: John Wiley & Sons, Inc., 1996.
Walsh, William E. The Complete Guide to Understanding and Relieving Your Food Allergies. New York: John Wiley & Sons, Inc., 2000.
Zuffante, P., Leonard, C.M., Kuldau, J.M., Bauer, R.M., Doty, E.G., Bilder, R.M. Working memory deficits in schizophrenia are not necessarily specific or associated with MRI-based estimates of area 46 volumes. Psychiatry Res, 108 (2001): 187-209.
Andrew Saul, PhD
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