William Kaufman, M.D., PhD. 

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The authors of a 1996 study on niacinamide and osteoarthritis (Jonas WB, Rapoza CP, Blair WF. The effect of niacinamide in osteoarthritis: a pilot study. Inflammatory Research 45:330–334.) could have omitted the words "pilot study" from their title. Dr. William Kaufman had already published, 47 years earlier, his meticulous case notes for hundreds of patients, along with specific niacinamide dosage information applicable to both osteoarthritis and rheumatoid arthritis. In addition, the doctor added some remarkably prescient observations on the antidepressant-antipsychotic properties of B-3. Dr. Kaufman, whom his widow has described as a conservative physician, was nevertheless the first to prescribe as much as 5,000 mg niacinamide daily, in many divided doses, to improve range of joint motion.

A summation of his niacinamide therapy (pages 20-29 of his book) is posted at http://www.doctoryourself.com/kaufman5.html

The entire text of Dr. Kaufman’s The Common Form of Joint Dysfunction has been republished on the Internet for free online reading.

Chapter 1 ( http://www.doctoryourself.com/kaufman6.html ), containing a fascinating passage about "decreased running" (ADHD), presents Dr. Kaufman’s niacinamide treatment protocol. He also used ascorbic acid, thiamin, and riboflavin, all in large doses. As his rationale and measurement methods begin the chapter, some readers may wish to scroll down directly to the section on dosage ("Methods of Treatment") and read that first. The chapter closes with case histories and an insightful, practical discussion of patient management.

Chapter 2 ( http://www.doctoryourself.com/kaufman7.html ),

Four Complicating Syndromes Frequently Coexisting with Joint Dysfunction, discusses physical and psychological stresses, allergy, posture, obesity and other factors that may interact or interfere with niacinamide megavitamin therapy for arthritis.

Chapter 3 ( http://www.doctoryourself.com/kaufman8.html ),

Coordination of Treatment, is a brief summary of Dr. Kaufman’s practical recommendations for case management.

Chapter 4 (http://www.doctoryourself.com/kaufman9.html ),

Analysis of Clinical Data for the Untreated and Treated Population, presents Dr. Kaufman’s meticulous records of patients treated with niacinamide.

Chapter 5 ( http://www.doctoryourself.com/kaufman10.html ),

Some Inferences Concerning Joint Dysfunction, shows Dr. Kaufman’s remarkable foresight half a century into the future of orthomolecular medicine. In this chapter, he describes how the lack of a single nutrient can cause diverse diseases; the need for a new way of looking at arthritis, and reviews his treatment and what level of success to expect.

The book’s 248 references are posted at



A complete bibliography of Dr. Kaufman’s work will be found at http://www.doctoryourself.com/biblio_kaufman.html .

For additional reading:

by William Kaufman, M.D., Ph.D. (a 1998 letter) will be found at

"Vitamin Deficiency, Megadoses, and Some Supplemental History" (a 1992 letter by Dr. Kaufman) is posted at   http://www.doctoryourself.com/kaufman2.html

His comments on WHAT TOOK THE FDA SO LONG TO COME OUT IN FAVOR OF FOLIC ACID? are posted at http://www.doctoryourself.com/kaufman4.html

Also of interest:

Kaufman, W. Niacinamide therapy for joint mobility. Conn. State Med. J. 17:584-589, 1953

Kaufman, W. Niacinamide, a most neglected vitamin. 1978 Tom Spies Memorial Lecture. J. Int. Acad. of Preventive Med. 8:5-25,1983

Kaufman, W. Niacinamide improves mobility in degenerative joint disease. Abstract published in Program of the American Association for the Advancement of Science for its meeting in Philadelphia, May 24-30, 1986

In 2002, Dr. Kaufman’s papers were acquired by the University of Michigan, Special Collections Library, 7th Floor, Harlan Hatcher Graduate Library, Ann Arbor, Ml 48109. Email: special.collections@umich.edu Phone: 734-764-9377

Copyright 2003 Andrew Saul.

Andrew W. Saul


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