Lincoln was right. You really can
fool some of the people all of the time.
When the topic is vitamins, some of the most easily fooled are news
broadcasters and newspaper reporters.
IF YOU HAVE RECENTLY
HEARD THAT VITAMINS ARE HARMFUL, you may want to read this page, or at least as much of it as you need to get your perspective back.
[Are you looking for information on a particular vitamin? Please scroll down the page.]
How to Make People Believe Any Anti-Vitamin Scare
It Just Takes Lots of Pharmaceutical Industry Cash
by Andrew W. Saul, Orthomolecular Medicine News Service, October 20, 2011
trumpeted anti-vitamin news is the product of pharmaceutical company
payouts. No, this is not one of "those" conspiracy theories. Here's how
1) Cash to study authors. Many of
the authors of a recent negative vitamin E paper (1) have received
substantial income from the pharmaceutical industry. The names are
available in the last page of the paper (1556) in the "Conflict of
Interest" section. You will not see them in the brief summary at the
JAMA website. A number of the study authors have received money from
pharmaceutical companies, including Merck, Pfizer, Sanofi-Aventis,
AstraZeneca, Abbott, GlaxoSmithKline, Janssen, Amgen, Firmagon, and
2) Advertising revenue. Many
popular magazines and almost all major medical journals receive income
from the pharmaceutical industry. The only question is, how much? Pick
up a copy of the publication and count the pharmaceutical ads. The more
space sold, the more revenue for the publication. If you try to find
their advertisement revenue, you'll see that they don't disclose it. So,
just count the Pharma ads. Look in them all: Readers Digest http://orthomolecular.org/resources/omns/v06n11.shtml , JAMA, Newsweek, Time, AARP Today, NEJM, Archives of Pediatrics. Even Prevention magazine. Practically any major periodical.
3) Rigged trials. Yes, it is true and yes it is provable. In a recent editorial, we explained how trials of new drugs are often rigged at http://orthomolecular.org/resources/omns/v04n20.shtml
. Studies of the health benefits of vitamins and essential nutrients
also appear to be rigged. This can be easily done by using low doses to
guarantee a negative result, and by biasing the interpretation to show a
statistical increase in risk.
4) Bias in what is published, or rejected for publication.
The largest and most popular medical journals receive very large income
from pharmaceutical advertising. Peer-reviewed research indicates that
this influences what they print, and even what study authors conclude
from their data. http://orthomolecular.org/resources/omns/v05n02.shtml .
5) Censorship of what is indexed and available to doctors and the public.
Public tax money pays for censorship in the largest public medical
library on the planet: the US National Library of Medicine
(MEDLINE/PubMed). http://orthomolecular.org/resources/omns/v06n03.shtml. See also: http://orthomolecular.org/resources/omns/v06n05.shtml.
Don't Believe It?
How well were these pro-vitamin, anti-drug studies covered in the mass media?
- A Harvard study showed a 27% reduction in AIDS deaths among patients given vitamin supplements. (2)
- There have been no deaths from vitamins in 27 years. http://orthomolecular.org/resources/omns/v07n05.shtml
- Antibiotics cause 700,000 emergency room visits per year, just in the US. (3)
- Modern drug-and-cut medicine is at
least the third leading cause of death in the USA. Some estimates place
medicine as the number one cause of death. (4)
- Over 1.5 million Americans are
injured every year by drug errors in hospitals, doctors' offices, and
nursing homes. If in a hospital, a patient can expect at least one
medication error every single day. (5)
- More than 100,000 patients die every year, just in the US, from drugs properly prescribed and taken as directed. (6)
Countless comedians have made fun of the
incompetent physician who, when called late at night during a life-
threatening disease crisis, says, "take two aspirin and call me in the
morning." It's no longer funny. One of the largest pharmaceutical
conglomerates in the world ran prime- time national television
commercials that declared: "Bayer aspirin may actually help stop you
from dying if you take it during a heart attack." The company also
promotes such use of its product on the Internet. http://www.wonderdrug.com/ , formerly http://www.bayeraspirin.com/news/heart_attack.htm
Daily Aspirin Use Linked With Pancreatic Cancer
Here's something you may have not seen.
Research has shown that women who take just one aspirin a day, "which
millions do to prevent heart attack and stroke as well as to treat
headaches - may raise their risk of getting deadly pancreatic cancer. . .
. Pancreatic cancer affects only 31,000 Americans a year, but it kills
virtually all its victims within three years. The study of 88,000 nurses
found that those who took two or more aspirins a week for 20 years or
more had a 58 percent higher risk of pancreatic cancer." (7) Women who took two or more aspirin tablets per day had an alarming 86 percent greater risk of pancreatic cancer.
Study author Dr. Eva Schernhammer of
Harvard Medical School was quoted as saying: "Apart from smoking, this
is one of the few risk factors that have been identified for pancreatic
cancer. Initially we expected that aspirin would protect against
How about that.
Say: What if there was one, just one case of pancreatic cancer caused by a vitamin? What do you think the press would have said about that?
The fact is, vitamins are known to be
effective and safe. They are essential nutrients, and when taken at the
proper doses over a lifetime, are capable of preventing a wide variety
of diseases. Because drug companies can't make big profits developing
essential nutrients, they have a vested interest in agitating for the
use of drugs and disparaging the use of nutritional supplements.
(Orthomolecular Medicine News Service
editor Andrew W. Saul taught nutrition, health science and cell biology
at the college level, and has published over 100 reviews and editorials
in peer-reviewed publications. He is author or coauthor of ten books
and is featured in the documentary film Food Matters. His website is http://www.doctoryourself.com .)
1. Klein EA, Thompson Jr, IM, Tangen CM et al. JAMA. 2011;306(14):1549-1556. http://jama.ama-assn.org/content/306/14/1549
2. Fawzi WW, Msamanga GI, Spiegelman D,
Wei R, Kapiga S, Villamor E, Mwakagile D, Mugusi F, Hertzmark E, Essex
M, Hunter DJ. A randomized trial of multivitamin supplements and HIV
disease progression and mortality. N Engl J Med. 2004 Jul
3. Associated Press, Oct 17, 2006. http://www.msnbc.msn.com/id/15305033/
4. Null G, Dean C, Feldman M, Rasio D. Death by medicine. J Orthomolecular Med, 2005. 20: 1, 21-34. http://orthomolecular.org/library/jom/2005/pdf/2005-v20n01-p021.pdf
5. The Associated Press. Drug errors injure more than 1.5 million a year. July 20, 2006. http://www.msnbc.msn.com/id/13954142
6. Leape LL. Institute of Medicine
medical error figures are not exaggerated. JAMA, 2000. Jul
5;284(1):95-7; Leape LL. Error in medicine. JAMA, 1994. Dec
21;272(23):1851-7; Lazarou J, Pomeranz BH, Corey PN. Incidence of
adverse drug reactions in hospitalized patients: a meta-analysis of
prospective studies. JAMA, 1998. Apr 15;279(15):1200-5.
7. Fox M. Daily aspirin use linked with pancreatic cancer. Reuters, Oct 27, 2003. http://www.cnn.com/2003/HEALTH/10/27/cancer.aspirin.reut/index.html
DEATHS FROM VITAMINS?
The American Association
of Poison Control Centers, which maintains the
national database from 61 poison control centers, indicates that even
including intentional and accidental misuse, the number of vitamin fatalities is less than one death per year. http://www.doctoryourself.com/vitsafety.html
And, it turns out, that there is NO documented evidence that any one of those alleged "deaths" was due to a vitamin. No evidence whatsoever. http://www.doctoryourself.com/vitsafety.html
however, are an entirely different matter:
to some of the most widely used medicines — from insulin to a common
antibiotic — sent more than 700,000 Americans to emergency rooms each year,
landmark government research shows.” (Associated Press, Oct 17, 2006) http://www.msnbc.msn.com/id/15305033/
VITAMIN BASHING IS NONSENSE
The news media can be
absolutely relied on to trumpet any allegation that vitamins are harmful.
Vitamin E has been accused of actually causing deaths. Even multivitamins have been accused of causing deaths.
What Kind of Medical Study Would Have Grandma Believe that Her Daily Multivitamin is Dangerous?
Orthomolecular Medicine News Service, October 12, 2011
by Robert G. Smith, PhD
(OMNS, Oct 12, 2011) A newly released
study suggests that multivitamin and nutrient supplements can increase
the mortality rate in older women . However, there are several
concerns about the study's methods and significance.
The study was observational, in which participants filled out a survey
about their eating habits and their use of supplements. It reports only a
small increase in overall mortality (1%) from those taking
multivitamins. This is a small effect, not much larger than would be
expected by chance. Generalizing from such a small effect is not
- The study actually reported that taking supplements of B-complex,
vitamins C, D, E, and calcium and magnesium were associated with a lower risk of mortality.
But this was not emphasized in the abstract, leading the non-specialist
to think that all supplements were associated with mortality. The
report did not determine the amounts of vitamin and nutrient supplements
taken, nor whether they were artificial or natural. Further, most of
the association with mortality came from the use of iron and copper
supplements, which are known to be potentially inflammatory and toxic
when taken by older people, because they tend to accumulate in the body
[2,3,4]. The risk from taking iron supplements should not be generalized
to imply that all vitamin and nutrient supplements are harmful.
- The study lacks scientific plausibility for several reasons. It
tabulated results from surveys of 38,000 older women, based on their
recall of what they ate over an 18-year period. But they were only
surveyed 3 times during that period, relying only on their memory of
what foods and supplements they took. This factor alone causes the study
to be unreliable.
Some of these women smoked (~15%) or had previously (~35%), some drank
alcohol (~45%), some had high blood pressure (~40%), and many of them
developed heart disease and/or cancer. Some preexisting medical
conditions were taken into account by adjusting the risk factors, but
this caused the study to contradict what we already know about efficacy
of supplements. For example, the study reports an increase in mortality
from taking vitamin D, when adjusted for several health-relevant
factors. However, vitamin D has recently been clearly shown to be
helpful in preventing heart disease  and many types of cancer ,
which are major causes of death. Furthermore, supplement users were
twice as likely to be on hormone replacement therapy, which is a more
plausible explanation for increased mortality than taking supplements.
- The effect of doctor recommendations was not taken into account. By their own repeated admissions, medical
doctors and hospital nutritionists are more likely to recommend a daily
multivitamin, and only a multivitamin, for their sicker patients.
The study did not take this into account. All it did was tabulate deaths
and attempt to correct the numbers for some prior health conditions.
The numbers reported do not reflect other factors such as developing
disease, side effects of pharmaceutical prescriptions, or other possible
causes for the mortality. The study only reports statistical
correlations, and gives no plausible cause for a claimed increase in
mortality from multivitamin supplements.
- The effect of education was not taken into account. When a doctor gives
advice about illnesses, well-educated people will often respond by
trying to be proactive. Some will take drugs prescribed by the doctor,
and some will try to eat a better diet, including supplements of
vitamins and nutrients. This is suggested by the study itself: the
supplement users in the survey had more education than those who did not
take supplements. It seems likely, therefore, the participants who got
sick were more likely to have taken supplements. Because those who got
sick are also more likely to die, it stands to reason that they would
also be more likely to have taken supplements. This effect is purely
statistical; it does not represent an increase in risk that taking
supplements of vitamins and essential nutrients will cause disease or
death. This type of statistical correlation is very common in
observational health studies and those who are health-conscious should
not be confounded by it.
- The known safety of vitamin and nutrient supplements when taken at
appropriate doses was not taken into account. The participants most
likely took a simple multivitamin tablet, which contains low doses.
Much higher doses are also safe [4,7], implying that the low doses in
common multivitamin tablets are very safe. Further, because each
individual requires different amounts of vitamins and nutrients, some
people must take much higher doses for best health .
Summary: In an observational study of older women in good health, it was
said that those who died were more likely to have taken multivitamin
and nutrient supplements than those who did not. The effect was small,
and does not indicate any reason for disease or death. Instead, the
study's methods suggest that people who have serious health conditions
take vitamin and mineral supplements because they know that supplements
can help. Indeed, the study showed a benefit from taking B-complex, C,
D, and E vitamins, and calcium and magnesium. Therefore, if those
wanting better health would take appropriate doses of supplements
regularly, they would likely continue to achieve better health and
(Robert G. Smith is Research Associate Professor, University of
Pennsylvania Department of Neuroscience. He is a member of the Institute
for Neurological Sciences and the author of several dozen scientific
papers and reviews.)
 Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR Jr (2011) Dietary
supplements and mortality rate in older women. The Iowa Women's Health
Study. Arch Intern Med. 171(18):1625-1633.
 Emery, T. F. Iron and your Health: Facts and Fallacies. Boca Raton, FL: CRC Press, 1991.
 Fairbanks, V. F. "Iron in Medicine and Nutrition." Chapter 10 in Modern Nutrition in Health and Disease, editors M. E. Shils, J. A. Olson, M. Shike, et al., 9th ed. Baltimore, MD: Williams & Wilkins, 1999.
 Hoffer, A., A. W. Saul. Orthomolecular Medicine for Everyone: Megavitamin Therapeutics for Families and Physicians. Laguna Beach, CA: Basic Health Publications, 2008.
 Parker J, Hashmi O, Dutton D, Mavrodaris A, Stranges S, Kandala NB,
Clarke A, Franco OH. Levels of vitamin D and cardiometabolic disorders:
systematic review and meta-analysis. Maturitas. 2010 Mar;65(3):225-36.
 Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.
Vitamin D and calcium supplementation reduces cancer risk: results of a
randomized trial. Am J Clin Nutr. 2007 Jun;85(6):1586-91.
 Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin
C: intravenous use by complementary and alternative medicine
practitioners and adverse effects. PLoS One. 2010 Jul 7;5(7):e11414.
 Williams RJ, Deason G. (1967) Individuality in vitamin C needs. Proc Natl Acad SciUSA.57:16381641.
Also of Interest:
Orthomolecular Medicine News Service, April 29, 2010. Multivitamins
Dangerous? Latest News from the World Headquarters Of Pharmaceutical
Politicians, Educators and Reporters. http://orthomolecular.org/resources/omns/v06n15.shtml
HERE IS A SOURCE for reliable information from a publication that is peer-reviewed by a panel of 20 nutritionally-minded researchers and doctors who are in favor of vitamin supplementation: http://orthomolecular.org/resources/omns/index.shtml
VITAMIN E: ANTI-VITAMIN FERVOR or
E Attacked Again
Because It Works.
by Andrew W. Saul
Editor, Orthomolecular Medicine News
(OMNS Oct 14, 2011) The very first Orthomolecular Medicine
News Service release was on the clinical benefits of vitamin E. That was seven
years ago. (1) In fact, the battle over vitamin E has been going full-tilt for
over 60 years. (2)
Well, you can say one thing for vitamin critics: at least
they are consistent. Consistently wrong, but consistent.
A recent accusation against vitamin E is that somehow it increases
risk of prostate cancer. (3) That is nonsense. If you take close look at the
numbers, you will see that “Compared with placebo, the absolute increase
in risk of prostate cancer per 1000 person-years was 1.6 for vitamin E, 0.8 for
selenium, and 0.4 for the combination.” That works out to be a claimed 0.63%
increase risk with vitamin E alone, 0.24% increase in risk with vitamin E and
selenium, and 0.15% increase in risk for selenium alone.
Note the decimal points: these are very small figures. But
more importantly, note that the combination of selenium with vitamin E resulted
in a much smaller number of deaths. If vitamin E were really the
problem, vitamin E with selenium would have been a worse problem. Selenium
recharges vitamin E, recycling it and effectively rendering it more potent.
Something is wrong here, and it isn’t the vitamin E. Indeed, a higher dose of
vitamin E might work as well as E with selenium, and be more protective.
And, in fact, this study did show that supplementation was
beneficial. Vitamin E and selenium reduced risk of all-cause mortality by about
0.2%., and also reduced the risk of serious cardiovascular events by 0.3%. Vitamin
E reduced risk of serious cardiovascular events by 0.7%. But what you were
told, and just about all you were told, was “Vitamin E causes cancer!”
oldest political trick in the book is to create doubt, then fear, and then
conformity of action. The pharmaceutical industry knows this full well. One
does not waste time and money attacking something that does not work. Vitamin E
works, and the evidence is abundant.
Specifically in regards to prostate cancer, new research
published in the International Journal of Cancer has shown that gamma-tocotrienol, a cofactor found in
natural vitamin E preparations, actually kills prostate cancer stem cells. (4)
As you would expect, these are the very cells from which prostate cancer
develops. They are or quickly become chemotherapy-resistant. And yet natural
vitamin E complex contains the very thing to kill them. Mice given
gamma-tocotrienol orally had an astonishing 75% decrease in tumor formation. Gamma-tocotrienol
also is effective against existing prostate tumors. (5,6)
* Vitamin E reduces
mortality by 24% in persons 71 or older. Even persons who smoke live longer
if they take vitamin E. Hemila H, Kaprio J. Age Ageing, 2011. 40(2): 215-220. January
* Taking 300 IU vitamin E per day reduces lung cancer by 61%.
(Mahabir S, Schendel K, Dong YQ et al. Dietary alpha-, beta-, gamma- and
delta-tocopherols in lung cancer risk. Int J Cancer. 2008 Sep
1;123(5):1173-80.) http://www.ncbi.nlm.nih.gov/pubmed/18546288 For further
information: Vitamin E prevents lung cancer. Orthomolecular Medicine News Service, Oct 29, 2008. http://orthomolecular.org/resources/omns/v04n18.shtml
* Vitamin E is an
effective treatment for atherosclerosis. Drs. Wilfrid and Evan Shute knew
this half a century ago. (1) In 1995, JAMA published research that confirmed
it, saying: “Subjects with supplementary vitamin E intake of 100 IU per day or
greater demonstrated less coronary artery lesion progression than did subjects
with supplementary vitamin E intake less than 100 IU per day.” (Hodis HN, Mack
WJ, LaBree L et al. Serial coronary angiographic evidence that antioxidant vitamin
intake reduces progression of coronary artery atherosclerosis. JAMA, 1995. 273:1849-1854.)http://jama.ama-assn.org/content/273/23/1849.short
* 400 to 800 IU of vitamin E daily reduces risk of heart attack by 77%.
(Stephens NG et al. Randomized controlled trial of vitamin E in patients with
coronary artery disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet,
March 23, 1996; 347:781-786.) http://www.ncbi.nlm.nih.gov/pubmed/8622332
* Increasing vitamin E with supplements prevents COPD [Chronic obstructive
pulmonary disease, emphysema, chronic bronchitis] (Agler AH et al. Randomized
vitamin E supplementation and risk of chronic lung disease (CLD) in the Women's
Health Study. American Thoracic Society 2010 International Conference, May 18,
2010.) Summary at http://www.thoracic.org/newsroom/press-releases/conference/articles/2010/vitamine-e.pdf
* 800 IU vitamin E per day is a successful treatment for fatty liver
disease. (Sanyal AJ, Chalasani N, Kowdley KV et al. Pioglitazone, vitamin
E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010 May
* Alzheimer's patients who take 2,000 IU of vitamin E per day live
longer. (Pavlik VN, Doody RS, Rountree
SD, Darby EJ. Vitamin E use is
associated with improved survival in an Alzheimer's disease cohort. Dement
Geriatr Cogn Disord. 2009;28(6):536-40.) Summary at http://www.associatedcontent.com/article/719537/alzheimers_patients_who_take_vitamin.html?cat=5
See also: Grundman M. Vitamin E and Alzheimer disease: the basis for
additional clinical trials. Am J Clin Nutr. 2000 Feb;71(2):630S-636S. Free
access to full text at http://www.ajcn.org/cgi/content/full/71/2/630s
* 400 IU of Vitamin E per day reduces epileptic seizures in children by
more than 60%. (Ogunmekan AO, Hwang PA. A randomized, double-blind,
placebo-controlled, clinical trial of D-alpha-tocopheryl acetate [vitamin E],
as add-on therapy, for epilepsy in children. Epilepsia. 1989 Jan-Feb;
* Vitamin E
supplements help prevent amyotrophic lateral sclerosis (ALS). This important
finding is the result of a 10-year-plus Harvard study of over a million
persons. (Wang H, O'Reilly EJ, Weisskopf MG, et al. Vitamin E intake and risk
of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective
cohort studies. Am.
J. Epidemiol, 2011. 173 (6): 595-602. March 15) http://aje.oxfordjournals.org/content/173/6/595.short
* Vitamin E is more
effective than a prescription drug in treating chronic liver disease (nonalcoholic
steatohepatitis). Said the authors: "The
good news is that this study showed that cheap and readily available vitamin E
can help many of those with this condition.” Sanyal AJ, Chalasani N, Kowdley KV et al. Pioglitazone, vitamin E, or
placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010 May
What Kind of Vitamin
Which work best: natural or synthetic vitamins? The general debate
might not end anytime soon. However, with vitamin E, we already know. The best E
is the most natural form, generally called "mixed natural tocopherols and
tocotrienols." This is very different from the synthetic form, DL-alpha
tocopherol. In choosing a vitamin E supplement, you should carefully read the
label... the entire label. It is remarkable how many natural-looking brown
bottles with natural-sounding brand names contain a synthetic vitamin. And
no, we do not make brand recommendations. Furthermore, OMNS has no commercial
affiliations or funding.
Unfortunately, that’s not the case with some authors of the negative
vitamin E paper. (3) You will not see this in the abstract at the JAMA website,
of course, but if you read the entire paper, and get to the very last page
(1556), you’ll find the “Conflict of Interest” section. Here you will discover
that a number of the study authors have received money from pharmaceutical
companies, including Merck, Pfizer, Sanofi-Aventis,
AstraZeneca, Abbott, GlaxoSmithKline, Janssen, Amgen, Firmagon, and Novartis. In
terms of cash, these are some of the largest corporations on the planet.
Well how about that: a “vitamins are dangerous” article, in one of the
most popular medical journals, with lots of media hype . . . and the
pharmaceutical industry’s fingerprints all over it.
How Much Vitamin E?
More than the RDA, and that’s for certain. A common
dosage range for vitamin E is between 200 and 800 IU/day. Some orthomolecular physicians
advocate substantially more than that. The studies cited above will give you a
ballpark idea. However, this is an individual matter for you and your
practitioner to work out. Your own reading and research, before you go to your
doctor, will help you determine optimal intake. If your doctor quotes a
negative vitamin study, then haul out the positive ones. You may start with
this article. There are more links to more information at http://orthomolecular.org/resources/omns/v06n09.shtml
And as for the old saw argument that supplement-users are
supposedly dying like flies, consider this: Over 200 million Americans take
vitamin supplements. So where are the bodies? Well, there aren’t any. There has
not been a single death from vitamins in 27 years. http://orthomolecular.org/resources/omns/v07n05.shtml
. Share that with your doctor as well. And with the news media.
(Andrew W. Saul has been an
orthomolecular medical writer and lecturer for 35 years. He received the
Outstanding Health Freedom Activist Award from Citizen’s for Health, and is the
winner of three Empire
fellowships. Saul is author or coauthor of 10 books, four of which are with
Abram Hoffer, M.D..)
2. Saul AW. Vitamin E: A cure in search of recognition. J Orthomolecular Med, 2003. Vol 18, No 3 and 4, p
205-212. Free download at http://orthomolecular.org/library/jom/2003/pdf/2003-v18n0304-p205.pdf
or html at http://www.doctoryourself.com/evitamin.htm
. See also: Saul AW. Review of The vitamin E
story, by Evan Shute. J
Orthomolecular Med, 2002. Volume 17, Number 3, Third Quarter, p
3. Klein EA, Thompson Jr, IM, Tangen CM et al. JAMA. 2011;306(14):1549-1556.
Also, as an example of many media spins:
4. Sze Ue Luk1, Wei Ney Yap, Yung-Tuen Chiu et al.
Gamma-tocotrienol as an effective agent in targeting prostate cancer stem
cell-like population. International Journal of Cancer, 2011. Vol 128, No 9, p 2182–2191.
5. Nesaretnam K, Teoh HK, Selvaduray KR, Bruno RS, Ho E.
Modulation of cell growth and apoptosis response in human prostate cancer cells
supplemented with tocotrienols. Eur. J. Lipid Sci. Technol. 2008, 110, 23-31. http://onlinelibrary.wiley.com/doi/10.1002/ejlt.200700068/abstract
6. Conte C, Floridi A, Aisa C et al. Gamma-tocotrienol metabolism and
antiproliferative effect in prostate cancer cells. Annals of the New York Academy of Sciences, 2004. 1031: 391-4. http://www.ncbi.nlm.nih.gov/pubmed/15753178?dopt=AbstractPlus
Also of interest:
Vitamin E research ignored by major news media. Orthomolecular Medicine News Service, May 25, 2010 http://orthomolecular.org/resources/omns/v06n19.shtml You can read more about
the safety and effectiveness of vitamin E at http://www.doctoryourself.com/evitamin.htm
Another well-publicized bit of anti-vitamin E propaganda was: Miller E. R.,
Pastor-Barriuso R., Dalal D., Riemersma R. A., Appel L. J. & Guallar E.
Meta-Analysis: High-dosage vitamin E supplementation may increase all-cause
mortality. Ann Intern Med, 4 January 2005. Volume 142, Issue 1.
Simply put, this and
similar vitamin-bashing articles are wrong. Their conclusions are
pre-ordained; their approach is biased; their research design is faulty. In
the present study, even the study authors admitted that "Most of the
patients in the trials were over age 60 and were not well." (Billingsley
J. Vitamin E linked to higher death rates. HealthDay Reporter, Weds Nov. 10,
The reporter adds:
"The study 'inappropriately tries to draw conclusions for the whole
population based on a combination of studies of people who were already at
grave risk with existing diseases, including cancer, heart disease,
Alzheimer's, Parkinson's and kidney failure,'" according to the Council
for Responsible Nutrition, a dietary-supplement industry association.
"John Hathcock, the
Council's vice president for scientific and international affairs, added, 'In
reviewing the totality of evidence on vitamin E, including all clinical trial
data and several large observational studies, CRN agrees with the Institute
of Medicine in finding vitamin E supplements safe at levels of at least up to
1,000 mg (1,600 IU) for normal, healthy adults. This meta-analysis provides no
convincing evidence to the contrary.'"
In fact, writes Bill
Sardi: "The study authors concluded that 'Overall, vitamin E
supplementation did not affect all-cause mortality.' That is not what you
heard in televised news reports or in the newspapers. What you heard was
there is a 5 to 10 percent (5 to 10 in 100) increased risk of dying from
taking high-dose vitamin E supplements. . . (I)n hard numbers the risk rose
by 10 in 10,000 persons, or 1 in 1000 (about 1/10th of one percent). . . The
authors of the study indicate, among the 19 studies they examined, 'Most of
the trials examined targeted populations at high risk for a chronic disease,
most often coronary heart disease.' This fact obviously skewed the
Indeed, Sardi adds:
"A University of North Carolina study of 45,748 participants, aged 50 to
75 years, found that supplement use is higher among people who are battling
chronic health conditions and the strongest association was for
cardiovascular disease with supplemental vitamin E. [Am Journal Preventive
Medicine 24:43-51, 2003]."
To sum it up: Older
people are much more likely to have multiple chronic illnesses. Many such
people are likely to take higher doses of vitamin E, which while a lifesaver,
is not the elixir of immortality. Sadly, older people die. People die in
spite of vitamin E, not because of it.
SO WHY THE CONFUSION?
As I wrote in the DOCTOR
YOURSELF Newsletter (http://www.doctoryourself.com/news/v4n22.txt):
Meta-Analysis: A meta-analysis is not new research, but a review of existing
research. It is not a clinical study, but rather a statistical look at a
collection of studies. If you analyze failed studies, you will get a negative
meta-analysis. Low-dose vitamin studies are the ones that get negative
results. Most vitamin research is low-dose. So where's the surprise?"
Many if not most
E-supplementers mistakenly or unknowingly take synthetic vitamin E (DL-alpha
tocopherol), which is less effective (and some clinicians think is far less
effective) than the natural form. As cardiologists Wilfrid and Evan Shute
discovered decades ago, the natural "D" (dextro-, or right-handed)
form of the vitamin, plus the other natural mixed tocopherols (beta-, gamma-
and delta-tocopherol) are needed for best results. You cannot screw in a
left-hand-thread light bulb and expect your lamp to work.
Megadosing with natural
vitamin E has been shown to be safe and effective for well over 60 years.
VITAMIN E WITCH HUNT
by Michael Fumento
Less than two months ago I
debunked a report in the Lancet medical journal claiming antioxidants
slightly increase your chance of dying, rather than reducing it as most
researchers believe. Now I'm writing about a report that says the same thing
about a specific antioxidant, vitamin E.
Why are these pills being
persecuted? Among the similarities of the earlier report and this one,
authored by researchers at the
of Public Health, is that the mainstream media accepted both without
question. Both times the researchers smugly declared their work to be the
final word on the subject, though both reports were, as the vitamin E one
admitted, 'a qualitative departure from previous findings.'
Since a good scientist knows no
single report ever proves anything, we know these weren't good scientists. In
fact, they have less in common with Johns
than Matthew Hopkins -
infamous 'Witch-finder General.'
Consider the vitamin E paper, published
in The Annals of Internal Medicine (full citation at http://www.doctoryourself.com/safety.html).
It analyzed 19 clinical trials between 1993 and 2004, involving 136,000
people in all. These were combined into what's called a 'meta-analysis,'
which showed no overall increase in deaths. But at high levels, defined as
above 400 international units (IUs) per day, the researchers insisted
'vitamin E supplements may increase (deaths) and should be avoided.'
A glaring problem with the report
is that there have been far more than 19 vitamin E trials since 1993, and one
way the pack was whittled down was by excluding all studies reporting fewer
than 10 deaths. The witch-hunters weren't about to interrogate witnesses who
might keep the accused from a visit to the gallows.
Also, if 'more is worse,' why did
the two studies that used the highest dose, 2,000 IUs per day, indicate fewer
deaths among vitamin E users? Another problem with declaring this report to
be the final word on vitamin E is that while clinical trials are important,
epidemiological studies cannot be ignored. Yet ignored they were.
Thus there was no reference to the
1996 one from the National Institute of Aging that followed 11,000 elderly
persons for seven years and found that the death rate for vitamin E users was
a third that of non-users. Adding another antioxidant, vitamin C, cut
fatalities even more.
A 1993 Harvard study of 40,000
male health professionals found those who took at least 100 IUs daily for two
years had a third fewer cases of heart disease than those receiving no
vitamin E supplements.
A Harvard study of 87,000 nurses
that year found an even greater reduction in heart disease when comparing
women who took the highest amount of vitamin E vs. those taking the lowest
amount. Does this have you running in terror at the sight of a vitamin E
But what's with the supplement
witch-hunt? Why the reports of vitamin E flying on broomsticks, and beta
carotene casting hexes?
"Unfortunately, there are
some doctors who are biased against dietary supplements," says John
Hathcock, vice president of Scientific & International Affairs at the
D.C.-based Council for Responsible Nutrition. To an extent, this is understandable.
For one, some supplements are worthless while a few have proved harmful. But
you just can't lump 'eye of newt' in together with vitamin E or other
Mainstream medicine is also biased
toward that which has formal FDA approval. You know, like Vioxx. And never
mind the many supplements such as iron and iodine that have tacit FDA support
but no formal approval.
Some doctors also fret that people
will try to substitute supplements for good eating habits. 'We don't think
that people need to take vitamin E supplements, that they get enough from the
diet,' said the lead vitamin E prosecutor, associate professor Edgar Miller.
Yet the average American gets only
about 10 IU daily. With some studies showing 2,000 IUs to be beneficial,
dietary intake leaves us a bit shy of the mark. Anyway, those taking vitamins
and other supplements also have the best diets.
The final explanation for
vitamin-pill persecution is that medical journals are becoming increasingly
sensationalist. Publishing articles contrary to popular wisdom is a cheap and
easy way to get headlines.
But there's no excuse for throwing
a noose around the neck of good science and healthful products.
with the kind permission of the author. Michael Fumento (http://www.fumento.com) is a senior fellow
at Hudson Institute, syndicated columnist with Scripps Howard News Service
and author of BioEvolution: How Biotechnology is Changing our World.]
WELL-PUBLICIZED VITAMIN SCARES
FEED THE PHARMACEUTICAL INDUSTRY
CHICKEN LITTLE was in the medical library one day when a journal fell on
her head. She read it, and it scared her so much she trembled all over. Why?
Because Chicken Little had read of negative studies on vitamins. She was so
afraid that half her feathers fell out.
Vitamins are killing us! I have to go tell the President!"
So she ran in great
fright to tell the President. Along the way she met Henny Penny.
"Where are you
going, Chicken Little?" said Henny Penny.
"Oh, help! Vitamins
are killing us!" said Chicken Little.
"How do you
know?" said Henny Penny.
"I read it with my
own eyes," said Chicken Little, "And it was on the news, and part
of it fell on my head!"
killing us? This is terrible, just terrible!" said Henny Penny.
"We'd better hurry up."
So they both ran away as
fast as they could. Soon they met Ducky Lucky.
"Where are you
going, Chicken Little and Henny Penny?"
killing us! Vitamins are killing us!" said Chicken Little and Henny
Penny. "We're going to tell the President!"
"How do you know
vitamins are killing people?" said Ducky Lucky.
"I read it with my
own eyes," said Chicken Little, "And heard it with my own ears on
the news, and part of it fell on my head."
"Oh dear, oh
dear!" Ducky Lucky. "We'd better run!"
So they all ran down the
road as fast as they could. Soon they met Goosey Loosey walking down the
"Hello there. Where
are you all going in such a hurry?"
"We're running for
our lives!" said Chicken Little
killing us!" said Henny Penny.
"And we're running
to tell the President!" said Ducky Lucky.
How do you know that
vitamins are killing people?" said Goosey Loosey.
"I read it with my
own eyes," said Chicken Little, "And heard it with my own ears on
the news, and part of it fell on my head!"
said Goosey Loosey. "Then I'd better run with you."
And they all ran in great
fright across a field. Before long they met Turkey Lurkey strutting back and
Chicken Little, Henny Penny, Ducky Lucky, and Goosey Loosey. Where are you
all going in such a hurry?"
said Chicken Little. "Vitamins are killing us!"
"We're running for
our lives!" said Henny Penny.
"And by the way, the
sky is falling!" added Ducky Lucky.
"So we're running to
tell the President!" said Goosey Loosey.
"How do you know the
sky is falling?" asked Turkey Lurkey.
"I read it with my
own eyes," said Chicken Little, "And heard it on the news with my
own ears, and part of it fell on my head!"
"Oh dear!" said
Turkey Lurkey. "I always suspected those damned vitamins were dangerous!
I'd better run with you."
So they ran with all
their might, until they met Pharma Fred the Fox.
well," said Pharma Fred. Where are all of you rushing off to on such a
cried Chicken Little, Henny Penny, Ducky Lucky, Goosey Loosey, and Turkey
Lurkey all together. "It's not a fine day at all. Vitamins are killing
us, the sky is falling, and we're running to tell the president!"
"But of course
vitamins are killing you," said Pharma Fred the Fox. "Now all of
you calm down. Here, have a Prozac."
Chicken Little, Henny
Penny, Ducky Lucky, Goosey Loosey, and Turkey Lurkey each swallowed a few
Prozacs, and some Valium for good measure.
said Pharma Fred the Fox. "How did you learn of how dangerous those
vitamins really are?"
"I read it with my
own eyes," said Chicken Little, "And heard it on the news with my
own ears, and part of it fell on my head!"
"I see," said
Pharma Fred the Fox. "Well then, follow me, and I'll show you right to
So Pharma Fred the Fox
led Chicken Little, Henny Penny, Ducky Lucky, Goosey Loosey, and Turkey
Lurkey across a field and through the woods. He led them straight to his den,
and they never saw the President.
And Foxy Pharma Fred had
most a delicious dinner.
(With thanks and
courteous apologies to http://eleaston.com/chicken.html, an excellent language education resource where you
will find the original story.)
Now look here, everyone:
The sky is not falling.
Vitamins save lives. We are a nation of sick, under-nourished, and
over-medicated people. Vitamins are not the problem; they are the solution.
REMEMBER: There is
not even one death per year from vitamin supplements.
However, there are at least
100,000 deaths from pharmaceutical drugs each year in the
when taken as prescribed. (Lucian Leape, Error in medicine. Journal of the
American Medical Association, 1994, 272:23, p 1851. Also: Leape LL. Institute
of Medicine medical error figures are not exaggerated. JAMA. 2000 Jul
All deaths caused by
drugs and doctors may total as high as one million deaths per year. http://www.doctoryourself.com/deathmed.html
Do not be buffaloed and
do not be bullied. If someone tries to scare you from taking vitamins, ask
to see the scientific papers that they base such a warning on. Assuming
that the vitamin critic actually respects you enough to honor your request
and produce such documents, here's how to spot bias in a scientific study:
IF YOU ARE ASKED FOR YOUR
REASONS FOR TAKING VITAMINS, here are references that will support you:
Scroll further down this
page for a lengthy list of physicians whose writings will back you up.
IF YOU ARE TAKING
It is rare that a vitamin
will negatively interact with a medication.
On the other hand, it is common
for a medication to create an actual vitamin deficiency. To find out, check
in the Physicians' Desk Reference (PDR), which is freely available at any
library. Read up on your medication, paying special attention to any
drug-nutrient interactions. Base you decision on facts, not a person's
opinion or belief.
IF YOU ARE ON
IF YOU ARE HOSPITALIZED:
IF YOU NEED INTRAVENOUS
IF YOU NEED HELP
NEGOTIATING WITH YOUR DOCTOR:
IF YOU NEED HELP FINDING
PHYSICIAN AUTHORS THAT
CLEARLY STATE, "VITAMINS ARE SAFE AND EFFECTIVE":
Here's what highly
qualified and experienced medical doctors, that have used megavitamins for
decades, have to say about the safety of vitamin megadoses:
Abram Hoffer, M.D.,
Ewan Cameron, M.D.:
Robert F. Cathcart, M.D.:
Emannuel Cheraskin, M.D.,
Frederick R. Klenner,
William Kaufman, M.D.:
Thomas Levy, M.D.:
William J. McCormick,
Hugh D. Riordan, M.D.:
Wilfrid Shute, M.D. and
Evan Shute, M.D.:
Lendon Smith, M.D.:
Walt Stoll, M.D.:
Carl C. Pfeiffer, M.D.,
Hans A. Nieper, M.D.:
You will likely discover
that very few vitamin naysayers "have the time" to discuss the work
of the physicians listed above. That is precisely why you have the
responsibility to read it. Be prepared.
IF YOU HAVE BEEN TOLD NOT
TO TAKE VITAMIN A, please read this:
IF YOU HAVE BEEN TOLD NOT
TO TAKE NIACIN OR NIACINAMIDE (Vitamin B-3), please read this:
IF YOU HAVE BEEN TOLD NOT
TO TAKE ANY OF THE OTHER B-VITAMINS, please read this:
IF YOU HAVE BEEN TOLD NOT
TO TAKE VITAMIN C, please read this:
"OBJECTIONS" TO VITAMIN C MEGADOSES
"A lot of people go through life
trying to prove that the things that are good for them are wrong." (Ward
Cleaver, on "Leave it to Beaver")
In massive doses, vitamin
C (ascorbic acid) stops a cold within hours, stops bronchitis in a day, and
stops viral pneumonia (pain, fever, cough and the lot) in two days. It is a
highly effective antihistamine, antiviral and antibiotic. It is an antitoxin
and it reduces inflammation and lowers fever. Your doctor may not believe
this, but it is not a matter of belief. It is a matter of experience. Once
you see it happen repeatedly, you know it to be true.
Many people therefore
wonder, in the face of statements like these, why the medical professions
have not embraced vitamin C therapy with open and grateful arms. The reason
is this: Many studies that claimed to "test" vitamin effectiveness
were designed to disprove it.
You can set up any experiment
One way to ensure failure
is to make a meaningless test. A meaningless test is assured if you make the
choice to use inappropriate administration of insufficient quantities of the
substance to be investigated.
If you shoot beans at a
charging rhinoceros, you are not likely to influence the outcome. If I were
to give every homeless person I met on the street 25 cents, I could easily
prove that money will not help poverty. If a nutrition study uses less than
20,000 or 30,000 milligrams of vitamin C, it is unlikely to show any
antihistamine, antibiotic and antiviral benefit whatsoever.
That is because you have
to give enough to get the job done.
The public and their
doctors look to scientific researchers to test and confirm the efficacy of any
nutritional therapy. As long as such research as is done uses piddling little
doses of vitamins, doses that are invariably too small to work, megavitamin
therapy will be touted as "unproven."
"As evidence of
the value of nutrients, especially vitamin C... becomes more and more evident
to the public, researchers produce a mass of articles on minute aspects of
vitamin C. I have been consulted by many researchers who proposed bold
studies of the effects of massive doses of ascorbate. Every time the university
center, the ethics committee, the pharmacy committee, etc. deny permission
for the use of massive doses of ascorbate and render the study almost
useless. Seasoned researchers depending upon government grants do not even
try to study adequate doses. All of this results in a massive accumulation of
knowledge about very little which gives the impression that there is no more
of real importance to be learned. This accumulation of minutia hides the
great effects of ascorbate already known by some... As you read these learned
papers, you will realize that they seem to be completely unaware of the uses
of massive doses of ascorbate. One of the most amusing aspects of this
research are the speculations and research into the toxicity and other
adverse reactions of tiny doses of ascorbate when many have used for years 20
to 100 times the amounts being discussed." (from "Delay by
Intellectualization," by Robert Cathcart, M.D. http://www.orthomed.com Reprinted with permission.)
Probably the main
roadblock to widespread examination and utilization of this all-too-simple
technology is the equally widespread belief that there MUST be unknown
dangers to tens of thousands of milligrams of ascorbic acid. Yet, since the
time megascorbate therapy was introduced in the late 1940's by Fred R.
Klenner, M.D. (links to his work are posted above), and right up to today as
used by physicians such as Dr. Cathcart, there has been a surprisingly safe
track record and an even more surprisingly effective track record to follow.
mistakenly-believed "side effects" of vitamin C have been found to
be completely mythical. According to a NIH report published in the Journal
of the American Medical Association (April 21, 1999), NONE of the
following problems are caused by taking "too much vitamin C":
Allegations of Rebound
Destruction of vitamin B-12
Safety and effectiveness have
always been and should always be the benchmark for any therapeutic program.
When one considers that even the AMA admits to over 100,000 Americans dying
annually from routine administration of prescription drugs, I think we need
to consider anew the merits of truly large doses of vitamin C.
IF YOU HAVE BEEN TOLD NOT
TO TAKE VITAMIN D, please read this:
IF YOU HAVE BEEN TOLD NOT
TO TAKE VITAMIN E, please read this:
"There is a
principle which is a bar against all information, which is proof against all
argument, and which cannot fail to keep man in everlasting ignorance. That
principle is condemnation without investigation." (Herbert Spencer)
Copyright 2011, 2008, 2004
and prior years by Andrew W. Saul. Andrew Saul is the author of the books FIRE YOUR DOCTOR! How to be Independently
Healthy (reader reviews at http://www.doctoryourself.com/review.html
) and DOCTOR YOURSELF: Natural Healing
that Works. (reviewed at http://www.doctoryourself.com/saulbooks.html